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Center for Human Health and the Environment

New NIH Grant Support

Center members with new NIH grant awards on a yearly basis.

2021

Carolyn Mattingly, PI NIH/NIEHS/NCI R01 Comparative Toxicogenomics Database (CTD)  09/01/21-06/30/26 ($7,034,544) Co-PI: Allan Davis Co-Is: Cindy Grondin, Tom Wiegers, Jolene Wiegers, Daniela Sciaky, Robin Johnson Roy McMorran, Tony Planchart and David Reif

Carolyn Mattingly, PI NIH/NIEHS Highly Fluorinated Compounds – Social and Scientific Discovery: 3rd Annual Meeting 09/02/21-08/31/22 ($36,759)
Co-I: Detlef Knappe

Cathrine Hoyo, PI NIH/NIEHS UG3 Southern Liver Health Cohort 09/21/21-08/31/2027 ($17,000,000) Co-PIs: Cynthia Moylan (Duke), Joellen Schildkraut (Emory) NC State Co-Is: Antonio Planchart, David Skaar, Brian Reich, Jane Hoppin, Rachel Maguire, Jung-Ying Tzeng

Cathrine Hoyo, PI NIH/NIEHS R01 Novel Imprint Control Regions (ICRs) Responsive to Environmental Exposures 09/10/21-06/30/26 ($3,115,275)
Co-Is: Randy Jirtle, David Skaar, Jung-Ying Tzeng

Seth Kullman, PI NIH/NIEHS T32 Molecular Pathways to Pathogenesis Toxicology 07/17/21-6/30/26 ($1,468,285)
Co-I: Robert Smart

Kurt Marsden, PI NIH/NINDS R21 Cellular and Molecular Mechanisms of Behavioral Dysfunction in a Zebrafish Model of CHARGE Syndrome 09/10/21-02/28/23 ($411,240)

Kurt Marsden, PI NIH/NINDS R01 Molecular and Cellular Mechanisms of Acoustic Startle Threshold Regulation 04/01/21-03/31/26 ($1,868,238)

James Bonner, PI NIH/NIEHS R01 Mechanisms of Nanoparticle Modulation of Allergic Lung Disease 09/01/21-06/30/26 ($2,246,746)

Jun Ninomiya-Tsuji, PI NIH/NIGMS R35 TAK1 Signaling Pathway 01/01/21-12/31/2025 ($1,500,000)

2020

Carolyn Mattingly, PI NIH/NIEHS P42 Center for Environmental and Health Effects of PFAS 02/28/2020-01/31/25 ($8,257,235) Co-Is: Jane Hoppin, Detlef Knappe, Seth Kullman, Katyln May, David Muddiman, Antonio Planchart, Ranji Ranjithan, David Reif,

Robert Smart, PI NIH/NIEHS P30 Center for Human Health and the Environment 04/20/2020 ($7,600,673) Co-Is: Andrew Binder, James Bonner, David Collier, Jane Hoppin, Cathrine Hoyo, Keith Linder, Carolyn Mattingly, Katyln May, David Muddiman, David Reif

Michael Cowley, PI NIH/NIEHS R01 The Imprinted Gene Network in the Programming of Non-Alcoholic Fatty Liver Disease by Early Life Cadmium Exposure 05/19/2020-03/31/25 ($1,595,860)

Elizabeth Lucas, PI NIH/NIMH R01 A Sex-specific Circuit for Emotional Memory 06/1/2020-03/31/25 ($1,886,786) Co-I: Xinxia Peng

Shobhan Gaddameedhi, PI NIH/NIEHS R01 Circadian Clock Disruption: A Risk factor for Environmental Carcinogenesis 11/06/20-10/31/24 ($1,568,933)

Seth Kullman, PI NIH/NIEHS P42 Uncovering the Mechanisms of PFAS-induced Immunotoxicity 02/28/20-01/31/25 ($163,725)

Heather Patisaul, PI NIH/NIEHS Flame Retardant Effects on Thyroid Hormone Regulation at the Fetal-maternal Interface of the Placenta 06/11/20-06/10/25 ($1,446,661)

2019

Cathrine Hoyo, PI NIH/NCI R21 Hepatocellular Carcinoma, Epigenetics and Cadmium Exposure 02/01/2019 ($493,396)

Jodie Fleming, PI NIH/NCI R15, Engineering Novel Methods to Study Metastases and Reduce Systemic Treatment Toxicity in Breast Cancer Patients 02/04/2019 ($444,000)

David Reif, PI NIH/NIEHS R56 Gene-Environment Interactions Causing Differential Susceptibility to Chemical Exposure in High-Throughtput Screening 06/15/2019 ($224,999)

Siddhartha Thakur, PI, NIH/FDA U18 Enhancing the WGS Based Surveillance of Salmonella, Listeria, STEC and other Food Borne Related Bacterial Pathogens Isolated from Food and Environment at the National and Global Level 07/05/2019 ($164,651)

David Muddiman, PI NIH/NIA R56 Leveraging Glycomics to Characterize a Molecular Signature of Alzheimer’s Disease 8/1/2019 ($785,872)

Albert Keung, PI NIH/NCI R21 Intracellular CRISPR gRNA Assembly for Massively Multiplexed, One Pot, (EPI) Genetic Screening
09/01/2019 ($528,960)

David Skaar, PI NIH/NICHD R01 Characterizing the Human Imprint Regulatory Regions Associated with Childhood Obesity 09/06/2019 ($3,042,920) Co-I: Cathrine Hoyo

Zachary DeVries, PI – NIH/OD DP5 Histamine in Homes: Exposure Risks and Health Effects 09/16/2019 ($1,870,664)

2018

Kymberly Gowdy, PI – NIH/NIEHS R56 Novel Role For CD163 in Ozone Induced Alterations of Pulmonary Immunity 2/15/2018 to 1/31/2019 ($149,770)

Keith Keene, PI – NIH/NINDS R15 Genetic Evaluation of Two Novel Loci Associated with Recurrent Stroke
1/1/2018 to 12/31/2018 ($33,937)

Krista McCoy, PI – NIH/NIEHS R15 Nutraceutical Reduction of Endocrine Disrupting Chemical Induced Hypospadias
4/1/2018 to 3/31/2021 ($1,360,401)

Freya Mowat, PI – NIH/NEI K01 Responses of the Macula to Toxicant Injury: The Role(s) of PGC1α Isoforms in Photoreceptor Neuroprotection

Mentor: Chris McGhan
10/1/2018 to 9/30/2022 ($638,590)

Nanette Nascone-Yoder, PI – NIH/NICHD R01 Ahead of the Curve: Mechanisms of Left-Right Asymmetric Stomach Morphogenesis
8/17/2018 to 4/30/2023 ($1,547,945)

Hong Wang, PI – NIH/NIGMS R01 Sequence and Structure Specific DNA Binding by Cohesin and Genome Stability
1/1/2018 to 12/31/2021 ($837,444)

Jane Hoppin, PI – NIH/NIEHS R24 Maintaining and enriching the Infants Environmental Health Study (ISA) 09/30/18 to 06/30/23 ($1,131,121) Co-I: Brian Reich

Cathrine Hoyo, PI- NIH/NIEHS R24 Follow-up and Maintenance of the Newborn Epigenetics STudy (NEST) Cohort 09/30/18 to 06/30/23 ($1,920,179)

 2017

Michael Cowley, PI – NIH/NIEHS K22 Epigenetic Mechanisms Linking In Utero Cadmium Exposure to Hepatic Steatosis 9/15/2017 to 8/31/2020 ($483,000)

Jodie Fleming, PI – NIH/NIMHD U54 RCMI Center for Health Disparities Research. Project 1: Mechanisms linking Cancer Disparities and Metabolic Status 9/20/2017 to 6/30/2022 ($1,429,280)

Jane Hoppin, PI – NIH/NIEHS R21 Assessing Impact of Drinking Water Exposure to GenX (Hexafluoropropylene Oxide Dimer Acid) in the Cape Fear River Basin, North Carolina Co-I: Detlef Knappe, Katlyn May, Robert Smart 11/1/2017 to 10/31/2018 ($311,399)

Cathrine Hoyo and David Skaar, Co-PIs – NIH/NICHD R21 Identification of Human Imprint Regulatory Regions Associated with Obesity in Children
Co-I: Randy Jirtle 8/2/2017 to 7/31/2019 ($416,625)

Cathrine Hoyo, PI – NIH/NIMHD R01 Social Adversities, Epigenetics, and the Obesity Epidemic Co-I: Joan Kaufman 8/18/2017 to 5/31/2022 ($4,220,670)

Seth Kullman, PI – NIH/NIEHS P42 Duke University Superfund Research Center: Developmental Exposures: Mechanisms, Consequences and Remediation. Project 2: Altering the Balance of Adipogenic and Osteogenic Regulatory Pathways from Early Life Exposure to Halogenated Phenolic Contaminants and Organophosphates 4/1/2017 to 3/31/2022 ($496,425)

Jennifer Luff, PI – NIH/OD K01 Mechanisms of Interferson Regulatory Factor Dyfunction by Cutaneous Papillomaviruse 9/15/2017 to 6/30/2022 ($646,650)

Trudy Mackay, PI – NIH/NIDA U01 Genetics of Cocaine and Methamphetamine Sensitivity in Drosophila Co-I: Robert Anholt
9/15/2017 to 5/31/2022 ($2,826,180)

Carolyn Mattingly, PI – NIH/NIEHS R01 Comparative Toxicogenomics Database 6/1/2017 to 5/31/2022 ($2,876,695)

Ailson Motsinger-Reif, PI – NIH/NCI R01 Genetic Etiology of Cancer Drug Response Co-Is: Howard McLeod, Tim Wiltshire
4/1/2017 to 3/31/2022 ($2,180,275)

Heather Patisaul, PI – NIH/NIEHS R01 The Placenta: a Novel Target of Sex Specific Neurotoxicity by Fire Retardants 8/1/2017 to 7/31/2022 ($2,607,819)

Emilie Rissman, PI  – NIH/NIDA R21 Addiction, Gender and Endocrine Disruptors Co-I: Wendy Lynch 4/1/2017 to 3/31/2018 ($203,397)

Siddhartha Thakur, PI – NIH/FDA U01 Monitoring Anitmicrobial Resistance (AMR) in Salmonella, Campylobacter, Escherichia Coli and Enterococcus SPP. Isoloated from Retail Meats in NC 9/1/2017 to 8/31/2022 ($650,000)

Shuang Lim, PI – NIH/NIEHS R21 Rotational Tracking of Single Nanoplasmonic Upconverting Nanaparticle-Conjugated Proteins on DNA Co-I: Hong Wang 2/1/2017 to 12/31/2017 ($385,038)

2016

David Aylor, PI – NIH/NIEHS U01 Systems Toxicogenomics of Endocrine Disrupting Chemicals in Brain Co-I’s: Gregory Crawford, Heather Patisaul, Timothy Wiltshire 6/1/2016 to 4/30/2020 ($2,345,670)

Troy Ghashghaei, PI – NIH/NINDS R01 Role of Ependyma in Forebrain Homeostasis Co-I: Kenneth Adler 7/1/2016 to 3/31/2021 ($1,627,316)

Kymberly Gowdy, PI – NIH/NIEHS Cell Sorter Grant for ECU Flow Cytometry Core Facility 5/1/2016 to 4/30/2017 ($509,108)

Jane Hoppin, PI – NIH/NIEHS R21 Environmental Pesticide Exposure and Respiratory Outcomes in Women and Children Co-I’s: Christian Lindh, Ana Maria Mora, Brian Reich, Manuel Soto-Martinez
2/1/2016 to 1/31/2018 ($351,007)

Carolyn Mattingly, PI – NIH/NIEHS R01 Comparative Toxicogenomics Database 9/5/2016 to 11/30/2016 ($226,606)

John Meitzen, PI – NIH/NIMH R01 Elucidating the Mechanisms by which Estradiol Regulates Female Striatal Neuron Excitability
Co-I: Heather Patisaul 5/19/2016 to 2/28/2021 ($1,834,428)

Ricardo Richardson, PI – NIH/NCI U54 NCCU-Lineberger Comprehensive Cancer Center Partnership in Cancer Research 9/1/2016 to 8/31/2020 ($4,628,832)

Heather Shive, PI – NIH/OD K Identification of Genetic Collaborators in Cancer with a Brca2-mutant Zebrafish Model Mentors Matthew Breen, Robert Smart, Jeffrey Yoder 3/1/2016 to 2/28/2021 ($634,500)

Robert C. Smart, PI – NIH/NIEHS R01 Role of Long Intergenic Noncoding RNA in UVB-induced Apoptosis and Skin Cancer Co-Is: Michael Bereman, Jonathan Hall, Keith Linder, Fred Wright 6/1/2016 to 5/31/2021 ($1,679,160)

2015

Robert C. Smart, PI – NIH/NIEHS P30 Center for Human Health and the Environment Co-I: David Baltzegar, Michael Bereman, James Bonner, Jane A. Hoppin, Cathrine Hoyo, Keith Linder, Carolyn Mattingly, Katlyn May, Chris McGahan, Heather Patisaul, David Reif, Phillip Sannes, Heather Shive, Fred Wright 1/20/2015 to 3/31/2020 ($6,167,362)

Carolyn Mattingly, PI – NIH/NIEHS R01 Advancing Mechanism-Based Studies with Cross-species Chemical-Phenotype Data 1/1/2015 to 12/31/2019 ($1,497,059)

Emilie Rissman, PI – NIH/NIEHS R01 Transgenerational Actions of the Endocrine Disrupting Compound Bisphenol A 3/1/2015 to 2/28/2019 ($1,354,056)

Jun Tsuji, PI – NIH/NIGMS R01 TAK1 Regulation of Metabolism
Co-I’s: Troy Ghashghaei, Yoshiaki Tsuji 8/1/2015 to 7/31/2019 ($1,172,603)