Comparative Toxicogenomics Database (CTD) (Liaison: Dr. Carolyn Mattingly)
The CTD provides a resource that facilitates mechanistic discoveries underlying environmentally influenced diseases that can be tested experimentally. CHHE partnered with CTD to enhance the ability of members to translate mechanistic discoveries using model systems, while also providing insights into mechanisms that may underlie human health endpoints in population-based studies. CTD is a freely available database developed to promote understanding about the effects of the environment on human health and the etiologies for environmentally influenced diseases). Dr. Mattingly will provide consultation to CHHE members. CTD contains manually curated data describing: a) chemical-gene/protein interactions in vertebrates and invertebrates, b) chemical-disease relationships, c) gene/protein-disease relationships, and d) comprehensive exposure information. In addition to directly curated disease relationships, data integration in CTD allows users to computationally infer relationships among chemicals, genes, and diseases that can then be tested experimentally. Data curation is typically prioritized by chemical according to the foci of the NIEHS, EPA, FDA, and other groups. Consequently, CTD contains abundant data for diverse chemical compounds and drugs. CTD was expanded to include curated exposure data. This project will centralize and contextualize exposure data into a broader biological framework while grounding CTD’s experimental data in a “real-world” human exposure context. Partnering with CTD will provide specific advantages to CHHE members through several mechanisms. First, CTD will facilitate translation of basic science findings by virtue of the unique integration of cross-species chemical-gene interaction data with human disease information. Second, CTD will provide mechanism-based insights for population-based or clinical studies.