GenX Exposure Study (Liaison: Dr. Jane Hoppin)
Dr. Jane Hoppin leads the GenX Exposure Study which is a prospective study of NC residents whose drinking water is contaminated by GenX and other newly identified PFAS. It consists of 344 Wilmington, NC residents who have been exposed via surface water and 153 Fayetteville, NC, residents who live near the chemical plant and had PFAS contamination in their well water. Participants range in age from 6-86 and have provided blood, urine, and drinking water samples. In Fayetteville, participants also provided dust and wristband samples to assess ambient exposures to PFAS. All samples are analyzed for PFAS using non-targeted analysis. Biological samples have also been assessed for clinical outcomes (lipids, thyroid function, and comprehensive metabolic panel). Remaining biological (serum, plasma, whole blood, and urine) and environmental samples (dust and wristband extracts) are stored and available to CHHE investigators interested in PFAS topics. Additionally, due to the complexity of the exposure data, we will make these data sets available to CHHE investigators interested in analysis of complex mixtures, geospatial analyses, and other challenging statistical questions. As an ongoing cohort, the study welcomes input for future stages of data collection to facilitate translation of basic science findings to epidemiology and vice versa. The GenX Exposure Study cohort is also open to science communication researchers interested in best practices to communicate complex exposure information with limited toxicology data to diverse communities with respect to age, gender, race, and socioeconomic status. This research effort is integrated closely with the CEC.