The Metabolomics Section within the Systems Technologies Core (STC) involves the analysis of the low molecular weight complement of cells, tissues, or biological fluids. Metabolomics makes it feasible to uniquely profile (metabotyping) the biochemistry of an individual, or system, apart from, or in addition to, the genome and proteome. The metabolomics profile includes signals for endogenous compounds, and exogenously derived components (e.g., metals, chemicals, and drugs), and can include study designs to examine metabolic flux. Metabolomics is used to determine the pattern of changes (and related metabolites) arising from disease, dysfunction, disorder, or from the therapeutic or adverse effects of xenobiotics.
The Specific Aims of the Metabolomics Section within the STC are:
AIM 1. Provide guidance in study design. To provide guidance in study design, sample collection, storage, processing, and analytical methods to best address the needs of a study. In addition, the RCMRC will provide direction in appropriate data analysis, pathway mapping, and data integration approaches.
AIM 2. Provide expertise in broad-spectrum metabolomics and analysis of targeted analytes. To conduct broad spectrum metabolomics and metallomics, and use targeted methods for the analysis of specific endogenous or exogenous compounds.
AIM 3. Provide expertise in data analysis and pathway mapping. To determine metabolite(s) that correspond with the phenotype under investigation, and will use specialized software for pathway mapping, and integrating disparate data streams.