Welcome to the CHHE Knowledge Base (CHHEK). This site is designed to support the CHHE community with information about other members, shared resources, and summary statistics about our diverse research community.
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James Bonner
Professor
NC State
College of Sciences
(919) 515-8615
http://bonnerlab.wordpress.ncsu.edu/
Our goal is to explore and investigate mechanisms of environmental lung diseases (asthma, fibrosis, cancer) caused by emerging toxicants that pose a threat to human health and the environment. Our work is focused on investigating mechanisms of pulmonary toxicity caused by engineered nanomaterials (ENMs); tiny particles or fibers designed at the atomic scale that are increasingly used in a variety of consumer products. Of particular interest is determining the toxic potential of ENMs in susceptible populations and individuals with pre-existing disease, especially asthma. My current NIEHS R01 grant entitled “Mechanisms of Nanoparticle Modulation of Allergic Lung Disease” is aimed at providing novel insights towards mechanisms of asthma exacerbation by engineered nanoparticles as well as nanoscale air pollution particles.
- Cell biology
- Chemistry
- Immunology
- Molecular biology
- Pathology
- Physiology
- Proteomics
- Toxicology
- Cell culture
- Cell sorting/flow cytometry
- Cell signaling (receptors, kinases, etc.)
- Experimental design - pathology considerations
- Histology
- Imaging - confocal
- Immunohistochemistry
- In situ hybridization (whole mount, sections)
- Omics - genome
- Omics - proteome
- PCR
- PCR quantitative/real-time
- Reactive oxygen species
- RNA isolation/quantitation
- Sectioning - fixed samples
- Transgenic animal generation - mammalian
- Western blot
- Single-cell Approaches
- Seahorse
- Aeroallergens
- Air pollution
- Metals
- Nanoparticles
- Microplastics