Matthew Breen

Bio

Dr. Breen is a Professor of Genomics and the Oscar J. Fletcher Distinguished Professor of Comparative Oncology Genetics in the Dept. of Molecular Biomedical Sciences at the NCSU College of Veterinary Medicine. He is also a member of the NCSU Comparative Medicine Institute (CMI), the Center for Human Health for the Environment (CHHE), the NCSU Genetics Program in the College of Science, and the Cancer Genetics Program at the University of North Carolina’s Lineberger Comprehensive Cancer Center. Dr. Breen was a charter member, and now serves on the Board of Directors, of the Canine Comparative Oncology and Genomics Consortium (CCOGC), a 501c3 not-for-profit organization established to promote the role of the dog in comparative biomedical research. He is also a charter member of the Sea Lion Cancer Consortium (SLiCC).
CERTIFICATIONS
Fellow, Royal Society of Biology

Area(s) of Expertise

COMPUTATIONAL BIOLOGY AND BIOINFORMATICS, GENETICS, VETERINARY CANCER CARE
Dr. Matthew Breen’s research focuses on genomics, genome mapping and the comparative aspects of canine cancer. In addition his lab is using high throughput molecular cytogenetics for anchoring emerging genome assemblies and for evaluating the changes to genome structure that occur during speciation. The lab is also developing new molecular assays for diagnostic and prognostic use in veterinary medicine.

Publications

• Contrasting pathogen prevalence between tick and dog populations at Chornobyl , PARASITES & VECTORS (2024)
• Hemangiosarcoma Cells Promote Conserved Host-derived Hematopoietic Expansion , CANCER RESEARCH COMMUNICATIONS (2024)
• Molecular Discovery of Filarial Nematode DNA in an Endangered Wild Pinniped (Galapagos Sea Lion, Zalophus wollebaeki) , Ecology and Evolution (2024)
• The development of non-destructive sampling methods of parchment skins for genetic species identification , PLOS ONE (2024)
• Defining the relevance of surgical margins. Part two: Strategies to improve prediction of recurrence risk , VETERINARY AND COMPARATIVE ONCOLOGY (2023)
• Dirofilaria immitis Identified in Galapagos Sea Lions (Zalophus wollebaeki): A Wildlife Health and Conservation Concern , Journal of Wildlife Diseases (2023)
• The dogs of Chernobyl: Demographic insights into populations inhabiting the nuclear exclusion zone , SCIENCE ADVANCES (2023)
• Whole exome sequencing analysis of canine urothelial carcinomas without BRAF V595E mutation: Short in-frame deletions in BRAF and MAP2K1 suggest alternative mechanisms for MAPK pathway disruption , PLOS GENETICS (2023)
• Evaluating the relevance of surgical margins. Part one: The problems with current methodology , VETERINARY AND COMPARATIVE ONCOLOGY (2022)
• Inter-pathologist agreement on diagnosis, classification and grading of canine glioma , VETERINARY AND COMPARATIVE ONCOLOGY (2022)