Our vision is that the Center for Human Health and the Environment (CHHE) will serve as the nexus of environmental health science (EHS) research at NC State by providing focus and leadership for interdisciplinary research. Our aim is to understand how human health, at both the individual and population level, is impacted by environmental factors and to implement this knowledge to prevent and/or reduce the adverse impacts of environment factors on human health.
CHHE is a NIEHS funded Environmental Health Science Core Center. CHHE is approximately 1 of 20 Centers across the United States.
CHHE has developed three interdisciplinary Research Teams that integrate and build on NC State’s unique research strengths and resources in quantitative biology and diverse model organisms as well as its emerging strength in human population science to advance discovery in EHS along the continuum from genes to populations.
- The Molecular/Cellular-Based Systems and Model Organisms Team utilizes cutting edge genetic/molecular/cellular-based systems and powerful vertebrate and invertebrate model organisms to conduct fundamental research to define mechanisms by which environmental exposures promote disease.
- The Human Population Science Team is composed of experts on environmental exposures, epidemiology, genomics, and epigenomics who aim to identify key human pathways and link exposure and disease across populations.
- The Bioinformatics Team develops novel computational tools and analytics to translate Big Data generated across high-throughput and multiscale experiments into systems-level discoveries.
CHHE has developed three facility cores that increase the impact and the basic science and translational capacity of its Research Teams.
- The Systems Technologies Core provides cutting-edge technologies involving proteomics, metabolomics and genomics along with dedicated bioinformatics support.
- The Comparative Pathology Core provides pathologic phenotypic assessment of the many model organisms used by CHHE members.
- The third core, the Integrative Health Science Facility Core, enables CHHE investigators to translate basic science discoveries to clinical and public health outcomes and vice versa.
The multi-directional Community Outreach and Engagement Core disseminates CHHE’s findings and educates communities about environmental influences on health. A strong Career Development Core for early stage scientists is coordinated with a robust Pilot Project Program that supports cutting-edge, collaborative, and multidisciplinary EHS projects to enhance research success and impact.
CHHE now brings together 92 investigators from 13 departments and six colleges at NC State and as well as investigators from East Carolina University (ECU), Brody School of Medicine (BSOM), North Carolina Central University (NCCU), NC Department of Health and Human Services (NC DHHS) and NIH Eastern Regional Comprehensive Metabolomics Resource Core (RCMRC) at UNC-CH.
Through the purposeful interfacing of different disciplines and a systems biology framework integrating all levels of biological organization – biomolecule, pathway, cell, tissue, organ, model organism, human, and human population, CHHE aims to elucidate fundamental mechanisms through which environmental stressors interface with pathways, the genome and epigenome to influence human health outcomes.
Center for Human Health and the Environment
Campus Box 7633
NC State University
Raleigh, NC 27695-7633
CHHE Administrative offices (Suite 1104F-M) are located are located at 850 Main Campus Drive on Centennial Campus.
email address: firstname.lastname@example.org
CHHE Program Manager