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Systems Technologies Core

Provides cutting-edge technologies and expertise involving genomics, metabolomics, metallomics, and proteomics. 

Expertise in analytical techniques is essential to support CHHE’s mission to understand how human health is impacted by environmental factors and to implement this knowledge to reduce the adverse impacts.

The STC provides CHHE investigators with analytical expertise and state-of-art methodologies to create an integrative, mechanistic picture of the underlying effects of environmental exposures on human health.

These methodologies include: 1) genomics, epigenomics, and transcriptomics; 2) discovery and targeted proteomics; 3) discovery and targeted metabolomics including environmental toxicants; and 4) metallomics including metal speciation.

Services & Support

Expert navigators for each section of the STC provide expertise, guidance and consultation on experimental design. 

To learn more about the core and how to access the services portal watch this short video.

STC Voucher Program

All full center members are eligible for the Systems Technology Core (STC) Voucher Program. Under this program, CHHE provides 50% of the costs up to $15K/member for $30K STC services for projects with EHS relevance.  

To participate, complete a STC voucher request, which includes estimated costs and a project description. The major approval criterion will be that funds must be used for EHS-related projects.

Update: Due to the pandemic and research restart, from July to December 31, 2021 CHHE full members can use their STC funds to get NGS sequencing done at external vendors such as Duke, UNC-CH, Novagene etc. CHHE will reevaluate this temporary change at the end of 2021.

Startup Stock Photos

Note: CHHE full members can now use STC Voucher Program funds for STC services that are part of a CHHE pilot project. For example, if a member is planning to use $10K for STC services in their pilot project then they would only need to include $5K in their budget and indicate the other $5K is being covered by the STC Voucher Program. The budget of PP remains capped at $25K but in effect with the voucher the member is receiving $30K. This is a bonus for CHHE full members. 

Ingenuity Pathway Analysis (IPA)

An IPA software license is purchased yearly by CHHE for access by all members and cores. IPA has broad adoption by the life science research community and is cited in thousands of articles for the analysis, integration, and interpretation of data derived from -omics experiments, such as RNA-seq, small RNA-seq, microarrays including miRNA and SNP, metabolomics, and proteomics. Mummichug in MetaboAnalyast and KEGG pathway analysis in Compound Discoverer are also used.