Area(s) of Expertise

Our laboratory investigates fundamental questions in cell biology and biochemistry, focusing on how RNA-centered molecular interactions regulate gene expression in normal, stress, and disease contexts. Using human cell models, we study how RNA structures and modifications—including R-loops, RNA G-quadruplexes, and N6-methyladenosine (m6A)—recruit and reorganize protein networks across the nucleus and cytoplasm. We also investigate the noncanonical functions of RNA-processing factors in chromatin regulation, mRNA stability, localization, and translation.

We combine mass spectrometry-based proteomics with molecular and cellular biology, biochemistry, CRISPR/Cas9 genome editing, fluorescence imaging, bioinformatics, and next-generation sequencing. By integrating unbiased discovery with biochemical and cell-based mechanistic studies, we seek to understand how RNA-associated regulatory networks influence transcription, RNA metabolism, cellular stress responses, and genome stability.