2020

Project 202001
Title: Investigating PFAS occurrence in private wells in North Carolina uniquely impacted by land-applied biosolids using a novel non-targeted analytical workflow
PI: Erin Baker, Dept. of Chemistry, NC State
Co-I: Jane Hoppin, Dept. of Biological Sciences, NC State
Co-I: Detlef Knappe, Dept. of Civil,Construction, and Environmental Engineering, NC State
Co-I: Nadine Kotlarz, Dept. of Biological Sciences, NC State
Co-I: Catherine LePrevost, Dept. of Applied Ecology, NC State

Project 202002
Title: Uncovering PFOA-induced metabolic changes and their association with B-cell metabolic function
PI: Jamie DeWitt, Dept. of Pharmacology and Toxicology, ECU
Co-I: Tracey Woodlief, Dept. of Pharmacology and Toxicology, ECU

Project 202003
Title: Investigating immune system impacts of PFAS in a uniquely exposed population in North Carolina
PI: Jane Hoppin, Dept.of Biological Sciences, NC State
Co-I: Nadine Kotlarz, Dept.of Biological Sciences, NC State
Co-I: Dereje Jima, Center for Human Health and the Environment, NC State Co-I: Jamie DeWitt, Dept. of Pharmacology and Toxicology, ECU

Project 202004
Title: High-speed atomic force microscopy and DREEM imaging of DNA damage repair on chromatin
PI: Parminder Kaur, Dept. of Physics, NC State
Co-I: Hong Wang, Dept. of Physics, NC State

Project 202005
Title: Investigations on the role of indoor environmental stressor house dust mite in atopic dermatitis
PI: Santosh Mishra, Dept. of Molecular Biomedical Sciences, NC State
Co-I: Thierry Olivry, Dept. of Clinical Sciences, NC State

Project 202006
Title: A web platform for mapping global, publication based, spatial and temporal distributions of per and polyfluoroalkyl substances (PFAS)
PI: Helena Mitasova, Dept. of Marine, Earth and Atmospheric Sciences, NC State
Co-I: Jane Hoppin, Dept. of Biological Sciences, NC State

Project 202007
Title: Who are the toxic cyanobacteria potentially impacting humans in the Chowan River?
PI: Ryan Paerl, Dept. of Marine, Earth and Atmospheric Sciences, NC State
Co-I: Joel Sanchez, Dept. of Marine, Earth and Atmospheric Sciences, NC State
Co-I: Haley Plaas, UNC-Chapel Hill

Project 202008
Title: A low-cost mobile air-pollution sensor with geospatial mapping: A tool for community-engaged, environmental health disparity research
PI: Yoo Min Park, Dept. of Geography, Planning, and Environment, ECU
Co-I: Sinan Sousan, Dept. of Public Health, ECU

Project 202009
Title: Continuous Monitoring of Personal Health – Environment Interaction by a Wearable, Skin-Breathing Chemiresistive Sensor Array
PI: Qingshan Wei, Dept. of Chemical and Biomolecular Engineering, NC State
Co-I: Yong Zhu, Dept. of Mechanical and Aerospace Engineering, NC State

2019 Spring

Project 201901
Title: Assessing the Consequences of Inhalation Exposure to GenX on the Pulmonary Immune Response of Mice to Allergens and Microbial Agents
PI: James Bonner, Dept of Biological Sciences, NC State
Co-I: Jamie DeWitt, Dept. of Pharmacology & Toxicology, ECU
Co-I: Jane Hoppin, Dept. of Biological Sciences, NC State

Project 201902
Title: Epigenetic Dysregulation of Liver Detoxification Genes in Hepatocellular Carcinoma
PI: Delores J. Grant, Dept. of Biological and Biomedical Sciences, NCCU
Co-I: Cathrine Hoyo, Dept. of Biological Sciences, NC State
Co-I: Dereje Jima, Center for Human Health and the Environment, NC State

Project 201903
Title: Impact of Acute and Chronic Ozone Exposure on Bladder Dysfunction
PI: Johanna L. Hannan, Dept. of Physiology, ECU
Co-I: Kymberly Gowdy, Dept. of Pharmacology & Toxicology, ECU

Project 201904
Title: Neural Mechanisms of Social Disruption of the Flame Retardant Mixture Firemaster 550
PI: John Meitzen, Dept. of Biological Sciences, NC State
Collaborator: Heather Patisaul, Dept. of Biological Sciences, NC State

Project 201905
Title: Perturbation of Iron Homeostasis by Environmental Chemicals
PI: Yoshiaki Tsuji, Dept. of Biological Sciences, NC State
Co-I: Jun Ninomiya-Tsuji, Dept. of Biological Sciences, NC State

Project 201906
Title: Deciphering the Roles of Cohesin SA1 and SA2 in DNA Damage Response at Telomeres
PI: Hong Wang, Dept. of Physics, NC State

2019 Fall

Project 201907
Title: Exploring fish consumption as a route of human Per- and polyfluoroalkyl
substances (PFAS) exposure
PI: Scott Belcher , Dept. of Biological Sciences, NC State
Co-I: Katy May, Center for Human Health and the Environment, NC State
Co-I:Theresa Guillette, Dept. of Biological Sciences, NC State

Project 201908
Title: Cellular and molecular mechanisms of cyanotoxin mixture-induced neurotoxicity
PI: Kurt Marsden , Department of Biological Sciences, NC State
Co-I: Michael Bereman , Dept. of Biological Sciences, NC State

Project 201909
Title: The comorbid effects of arsenic exposure and alcohol abuse on hippocampal neurodegeneration
PI: S. Alex Marshall, Dept. of Biological and Biomedical Sciences, NCCU
Collaborator: Kevin Williams, Biomanufacturing Research Institute and Technology Enterprise

Project 201910
Title: Environmental Lead Surveillance to Improve Caries Risk Assessment in Primary Care
PI: Mark Moss, School of Dental Medicine, ECU
Co-I: David Collier , Pediatric Healthy Weight Research and Treatment Center, ECU
Consultant: Dereje Jima, Center for Human Health and the Environment, NC State

Project 201911
Title: NC STATE-RTI collaboration on multi-pollutant exposure monitor that measures real-time total PM and PM species
PI: Roger Narayan, Dept. of Biomedical Engineering, NC State
Co-I: Jonathan Thornburg, RTI International

Project 201912
Title: Degradation of Bacterial Permeability Family Member A1 (BPIFA1) by House Dust Mite (HDM) Abrogates Innate Immune Response
PI: Tongde Wu, Dept. of Pharmaceutical Sciences, NCCU

2018 Spring

Project 201801
Title: Gestational Effects of Low Dose Cd Exposure on Epigenetic Regulation of Metabolism
PI: Scott Belcher, Dept. of Biological Sciences, NC State
Co-I: Theresa C. Guillette, Dept. of Biological Sciences, NC State

Project 201802
Title: Zac1 and the Imprinted Gene Network in the Programming of Non-Alcoholic Fatty Liver Disease
PI: Michael Cowley, Dept. of Biological Sciences, NC State
Co-I: Marine Baptissart, Dept. of Biological Sciences, NC State

Project 201803
Title: The novel role for estrogen signaling in pulmonary eicosanoid metabolism after ozone
exposure
PI: Kymberly M. Gowdy, Dept. of Pharmacology and Toxicology, ECU
Co-I: Espen Spangenburg, Dept. of Physiology, ECU
Co-I: Johanna Hannan, Dept. of Physiology, ECU

Project 201804
Title: Are long non-coding RNAs the missing link in AhR mediated repression of mesenchymal stem cell differentiation?
PI: Seth Kullman, Dept. of Biological Sciences, NC State
Co-I: Jonathan Hall, Dept. of Biological Sciences, NC State
Co-I: David Reif, Dept. of Biological Sciences, NC State

Project 201805
Title: GenX and related perfluorinated compounds: a comparative analysis of trophic transfer and toxicity
PI: Carolyn Mattingly, Dept. of Biological Sciences, NC State
Co-I: Antonio Planchart, Dept. of Biological Sciences, NC State
Co-I: David Buchwalter, Dept. of Biological Sciences, NC State

Project 201806
Title: Impacts of GenX (2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)- propanoate) on reproductive function and transcriptome signature in Caenorhabditis elegans
PI: Xiaoping Pan, Dept. of Biology, ECU
Co-I: David N. Collier, Dept. of Pediatrics, ECU
Co-I: Detlef R. U. Knappe, Dept. of Civil, Construction, and Environmental Engineering, NC State

Project 201807
Title: Novel statistical methods for estimating the health effects of chemical mixtures
PI: Brian Reich, Dept. of Statistics, NC State
Co-I: Denis Fourches, Dept. of Chemistry, NC State
Co-I: Jane Hoppin, Dept. of Biological Sciences, NC State

Project 201808
Title: A novel role of CDK4 in the transcriptional regulation of chromosome stability genes
PI: Marcelo Rodriguez-Publa, Dept. of Molecular Biomedical Sciences, NC State
Co-I: Michael Bereman, Dept. of Biological Sciences, NC State

Project 201809
Title: Histamine in homes: Spatial distribution and exposure risks
PI: Coby Schal, Dept. of Entomology & Plant Pathology, NC State
Co-I: Zachary DeVries, Dept. of Entomology & Plant Pathology, NC State

2018 Fall

Project 201810
Title: A tissue‐specific model to study heterogeneous mast cell phenotype using extracellular matrix hydrogels.
PI: Glenn Cruse, Dept. of Molecular Biomedical Sciences, NC State
Co-I: Donald Feytes, Joint Dept. of Biomedical Engineering, UNC/NC State

Project 201811
Title: Aromatic Hydrocarbon-Induced Carcinogenesis in Multiple Oxygen Environments.
PI: Michael P. Gamcsik, Dept. of Biomedical Engineering, NC State

Project 201812
Title: High-speed AFM imaging of the dynamics of mitochondrial DNA replication encountering DNA lesions.
PI: Parminder Kaur, Dept. of Physics, NC State
Co-I: Hong Wang, Dept. of Physics, NC State

Project 201813
Title: Finding Correlations between Asthma Exacerbation, Physiological Measurements and Environmental Factors.
PI: Edgar Lobaton, Dept. of Electrical and Computer Engineering, NC State
Co-I: Alper BozKurt, Dept. of Electrical and Computer Engineering, NC State

Project 201814
Title: Atrazine and Left-Right Asymmetric Birth Defects
PI: Nanette Nascone-Yoder, Dept. of Molecular Biomedical Sciences, NC State

Project 201815
Title: Bisphenol exposure biases the developing brain towards drug addiction
PI: Emilie Rissman, Dept. of Biological Sciences, NC State

2017

Project 201701
Title: Construction of 3 Dimensional Paper Microfluidic Devices for Detection of Toxins Present in Water Supplies.
PI: Michael Bereman, Dept. of Biological Science, NC State

Project 201702
Title: Development of a Predictive In vitro Bioassay to Screen Diverse Types of Carbon Nanotubes for Mesothelial Cell Transformation for Prevention of Mesothelioma
PI: James Bonner, Dept. of Biological Sciences, NC State
Co-I: Gregory Parsons, Dept. of Chemical and Biomolecular Engineering, NC State

Project 201703
Title: Delivering Mast Cell Targeting Oligonucleotides to the Lung as a Therapeutic Strategy for Asthma
PI: Glenn Cruse, Dept. of Molecular Biomedical Sciences, NC State
Co-I: Ken Adler, Dept. of Molecular Biomedical Sciences, NC State

Project 201704
Title: Impact of DNA Damage on Mitochondrial DNA Replication at the Single-Molecule Level
PI: Parminder Kaur, Dept. of Physics, NC State

Project 201705
Title: Sex-Specific Placental Accumulation and Disruption by the Flame Retardant Firemaster 550
PI: Heather Patisaul, Dept. of Biological Sciences, NC State
Collaborator: Heather Stapleton, Nicholas School of Environment, Duke University

Project 201706
Title: Elucidating the Connection Between Cadmium Mediated Hyperactivity and Down regulation of the E3 Ubiquitin Ligase, RNF2.
PI: Antonio Planchart, Dept. of Biological Sciences, NC State
Co-I: Carolyn Mattingly, Dept. of Biological Sciences, NC State

Project 201707
Title: Mapping Serum Exposome of Human Inflammatory Bowel Diseases
PI: Hongyu Ru, Dept. of Population Health and Pathobiology, NC State
Co-I: Kun Lu, Dept. of Environmental Sciences and Engineering, UNC-CH

Project 201708
Title: Allergic Contact Dermatitis from Disperse Dyes in Textiles
PI: Nelson Vinueza, Dept. Textile Engineering, Chemistry and Science, NC State
Co-I: Denis Fourches, Dept. of Chemistry, NC State
Co-I: Ronald Baynes, Center for Chemical Toxicology Research & Pharmacology, NC State

Project 201709
Title: Effects of In Utero Exposure to Bisphenol S on Pubertal Mammary Gland Development in MMTV-ErbB2 Transgenic Mice
PI: Xiaohe Yang, Dept. of Biological and Biomedical Sciences, NCCU

Project 201710
Title: Immune Suppression by Pyrene Exposure
PI:  Jeff Yoder, Dept of Molecular Biomedical Sciences, NC State
Co-I: Michael Bereman, Dept. of Biological Sciences, NC State
Co-I: Dereje Jima, Center for Human Health and the Environment and Bioinformatics Research Center, NC State
Co-I: Samuel Jones, Dept. of Clinical Sciences, NC State
Co-I: Katie Sheats, Dept. of Clinical Sciences, NC State

Project 201711
Title: Quantifying Adverse Impacts of Smoke Exposure from the Fall of 2016 Southeast Wildfires on North Carolina Public Health
PI: Fernando Garcia Menendez, Dept. of Civil, Construction, and Environmental Engineering, NC State
Co-I: Joseph P. Roise, Dept. of Forestry and Environmental Resources, NC State

Project 201712
Title: Benzoic acid in beverages; Establishing a link between urinary metatbolites, metabolic dysregulation and weight loss failure
PI: David N. Collier, Dept. of Pediatrics, ECU
Co-I: Carolyn Mattingly, Dept. of Biological Sciences, NC State

2016 Spring

Project 201601
Title: Behavior and specific gene alterations after prenatal exposure to arsenic
PI: Zuzana Drobna, Dept. of Biological Sciences, NC State

Project 201602
Title: Mechanisms of nanoparticle endocytosis and the subsequent effects on extracellular matrix
deposition and epithelial cell adhesion
PI: Jodie M. Fleming, Dept. of Biology, NCCU
Co-I: Michael Bereman, Dept. of Biological Sciences, NC State
Co-I: John J. Bang, Dept. of Environmental, Earth and Geospatial Sciences, NCCU
Co-I: James C. Bonner, Dept. of Biological Sciences, NC State

Project 201603
Title: Establishing a targeted genomic map of quantified transcriptional and epigenetic modifications associated with AhR mediated repression of mesenchymal stem cell differentiation.
PI: Seth W. Kullman, Dept. of Biological Sciences, NC State
Co-I: Michael Cowley, Dept. of Biological Sciences, NC State
Co-I: Yoshiaki Tsuji, Dept. of Biological Sciences, NC State

Project 201604
Title: Epigenetic modulation and hypothalamic leptin resistance in toxic metal exposures
PI: Jun Ninomiya-Tsuji, Dept. of Biological Sciences, NC State
Collaborator: Michael Cowley, Dept. of Biological Sciences, NC State

Project 201605
Title: Arsenic treatment of contaminated water using surface-functionalized fabrics
PI: Matthew Polizzotto, Dept. of Soil Science, NC State
Co-I: Stephen Michielsen, Dept. of Textile Engineering, Chemistry and Science, NC State
Co-I: David Buchwalter, Dept. of Biological Sciences, NC State
Co-I: Dean Hesterberg, Dept. of Soil Science, NC State
Co-I: Francois Birgand, Dept. of Biological & Agricultural Engineering, NC State

Project 201606
Title: The role of upstream stimulatory Factor in Tumor Suppression
PI: Michael Sikes, Dept. of Biological Sciences, NC State

Project 201607
Title: Characterization of pulmonary lymphocytes involved in exacerbation of environmental lung disease by microbial antigen
PI: Mary Jane Thomassen, Dept. of Internal Medicine, ECU
Co-I: Christopher Wingard, Dept. Physiology, ECU
Co-I: Robert Barrington, Dept. of Microbiology and Immunology, USA

Project 201608
Title: Telomeric cohesin complex and DNA damage induced telomere instability
PI: Hong Wang, Dept. of Physics, NC State

2016 Fall

Project 201609
Title: Investigating the Interplay between Genetic and Environmental Mechanisms Underlying Amyotrophic Lateral Sclerosis Etiology
PI: Michael S. Bereman, Dept. of Biological Sciences, NC State
Co-I: Carolyn Mattingly, Dept of Biological Sciences, NC State
Co-I: Debra Tokarz, Dept. of Population Health and Pathobiology, NC State
Co-I: Antonio Planchart, Dept of Biological Sciences, NC State

Project 201610
Title: The Role of C/EBPβ in Regulating p53 Pro-Apoptotic Transcriptional Activity in Response to UVB Solar Radiation
PI: Jonathan R. Hall, Dept. of Biological Sciences, NC State
Co-I: John S. House, Bioinformatics Research Center, NC State
Co-I: Yoshiaki Tsuji, Dept. Biological Sciences, NC State
Co-I: Robert C. Smart, Dept. Biological Sciences, NC State

Project 201611
Title: Reducing Pollutant-Induced Hypospadias: is Nrf2 Driving the Rescue?
PI: Krista A. McCoy, Dept. of Biology, ECU
Co-I: Michael Bereman, Dept. of Biological Sciences, NC State

Project 201612
Title: A Bioinformatics and Molecular Modeling Approach towards Understanding Epigenetic Targets and Genotoxic and Mutagenic Biological Pathways of Azo Dyes within Organisms
PI: Melissa A. Pasquinelli, Dept. of Textile Engineering, Chemistry, and Science, NC State
Co-I: Rachelle Bienstock, Dept. of Textile Engineering, Chemistry, and Science, NC State

Project 201613
Title: Impact of Phthalate Exposure on Paternal Programming of Offspring Neurological Phenotype
PI: Emilie Rissman, Dept. of Biological Sciences, NC State
Co-I: Sarah Robertson, Robinson Research Institute, Adelaide
Co-I: John Schjenken, Robinson Research Institute, Adelaide

Project 201614
Title: The Role and Regulation of p66Shc by Nrf2 in Cellular Antioxidant Response to Xenobiotics
PI: Yoshiaki Tsuji, Dept. of Biological Sciences, NC State
Co-I: Jun Ninomiya-Tsuji, Dept. of Biological Sciences, NC State
Co-I: Masaki Miyazawa, Dept. of Biological Sciences, NC State

2015

Project 201501
Title: Systems toxicology in genetically diverse mouse cells
PI: David L. Aylor, Dept. of Biological Sciences, NC State
Co-I: Michael Bereman, Dept. of Biological Sciences, NC State

Project 201502
Title: Establishment and implementation of a unique model for elucidating the mechanisms of action of endocrine disrupting compounds during early development
PI: Michael A. Cowley, Dept. of Biological Sciences, NC State
Co-I: Mchael Bereman, Dept. of Biological Sciences, NC State

Project 201503
Title: Discovery of biomarkers of effect following environmentally-relevant exposure to pharmaceutical pollutants
PI: Jamie C. DeWitt, Dept. of Pharmacology and Toxicology, ECU
Co-I: Krista McCoy, Dept. of Biology, ECU
Co-I: Eli Hvastkovs, Dept. of Chemistry, ECU

Project 201504
Title: Development and demonstration of methods for measurement of human exposure to air pollution using portable sensors applied to high potential dose scenarios in urban environments
PI: Christopher Frey, Dept. of Civil, Construction, and Environmental Engineering, NC State
Co-I: Kyle S. Bunds, Dept. of Parks, Recreation and Tourism Management, NC State
Co-I: Jonathan M. Casper, Dept. of Parks, Recreation and Tourism Management, NC State
Co-I: Andrew P. Grieshop, Dept. of Civil, Construction, and Environmental Engineering, NC State

Project 201505
Title: Pesticide exposure assessment of commercial lawn care operators
PI: Travis W. Gannon, Dept. of Crop Sciences, NC State
Co-I: Jane A. Hoppin, Dept. of Biological Sciences, NC State

Project 201506
Title: Immune-suppression by embryonic exposure to polycyclic aromatic hydrocarbons
PI: Jeffrey A. Yoder, Dept. of Molecular Biomedical Sciences, NC State
Co-I: David M. Reif, Dept. of Biological Sciences, NC State

2013

Project 201301
Title: Towards an unbiased multiplex exposure assay – coupling ultra-high pressure liquid chromatography and data independent acquisition (DIA) mass spectrometry
PI: Michael Bereman, Dept. of Biological Sciences, NC State

Project 201302
Title: Metabolic disrupting actions of the flame retardant mixture firemaster 550
PI: Heather Patisaul, Dept. of Biological Sciences, NC State

Project 201303
Title: Cellular and molecular studies of inorganic arsenic-induced deficiencies in the innate immune system
PI: Antonio Planchart, Dept. of Biological Sciences, NC State
Co-I: Carolyn Mattingly, Dept. of Biological Sciences, NC State
Co-I: David Reif, Dept. of Biological Sciences, NC State
Co-I: Jeffrey Yoder, Dept. of Molecular Biomedical Sciences, NC State

Project 201304
Title: Impact of transplacental arsenic exposure on keratinocyte stem cells
PI: Marcelo Rodriguez-Puebla, Dept. of Molecular Biomedical Sciences, NC State

Project 201305
Title: TRF1 and TRF2 in repair of UV-induced double-stranded DNA breaks
PI: Hong Wang, Dept. of Physics, NC State

2012

Project 201201
Title: Proteomic analyses of oxygenase expression in trichloroethylene (TCE) –degrading Mycobacteria
PI: Michael Hyman, Dept. of Microbiology, NC State

Project 201202
Title: Investigation of potential neurotoxicological impacts associated with chronic ingestion of manganese in North Carolina ground water
PI: Ricky L. Langley, NC Division of Public Health, DHHS
Co-I: Sandra L. Mort, NC Division of Public Health, DHHS
Co-I: Mina Shehee, DHHS, Epidemiology Section
Co-I: Tanya Barros, DHHS, Epidemiology Section
Co-I: Mercedes Hernandez-Pelletier, DHHS, Epidemiology Section

Project 201203
Title: Exposure to environmental toxicants, a mechanism of hypermutability of cardiomyopathy – linked genes
PI: Kathryn M. Meurs, Dept. of Clinical Sciences, NC State
Co-I: Jeffrey A. Yoder, Dept of Molecular Biosciences, NC State
Co-I: Mac Law, Dept of Population Health and Pathobiology, NC State

Project 201204
Title: Redefining the network of transcriptional responses to environmental genotoxins
PI: Michael Sikes, Dept of Microbiology, NC State

Project 201205
Title: Linking free radical chemistry and toxicity of engineered nanomaterials
PI: Tatyana I. Smirnova, Dept. of Chemistry, NC State
Co-I: Alex I Smirnova, Dept of Chemistry, NC State

2011

Project 201101
Title: Culturally and literacy modified signage for environmental safety awareness
PI: Greg Cope, Dept. of EM Toxicology, NC State
Co-I: Catherine LePrevost, PhD student, NC State

Project 201102
Title: Variance decompositions of genetic and exposure data pilot project
PI: Alison Motsinger-Reif, Dept. of Statistics, NC State
Co-I: Jane Hoppin, NIEHS and AHS