The Comparative Pathology Core (CPC) provides a single portal for CHHE member scientists to access unparalleled pathology expertise of a diverse range of animal models, covering laboratory rodents, fish and domestic animals.

Contact the CPC for all your pathology questions and/or consultation: chhe-cpcore@ncsu.edu

Ketih E. Linder, DVM, PhD, ACVP

Director, Comparative Pathology Core and Clinical Associate Professor, Dept. of Population Health and Pathobiology

As Director of the Comparative Pathology Core in the Center for Human Heath and the Environment, my goal is to provide collaborative pathology support to CHHE scientists to utilize the best animal model systems to study environmental health problems. As a board certified veterinary pathologist, I am interested to study whole animal systems and to understand multi-organ impacts of disease, especially in comparative animal models.  My focus is skin disease research and I have extensive experience in the pathology of animal models of skin disease and of naturally occurring animal skin diseases, including those with human counterparts.

 

Debra Tokarz, DVM, PhD, DACVP

Associate Director, Comparative Pathology Core

Vertebrate animal models provide a powerful tool for elucidating complex biological processes, but each species and strain comes with their own advantages, disadvantages, and unique pathological responses. By combining my research and pathology training, my goal is to help Center members effectively utilize vertebrate animal models to answer their research questions by aiding in experimental design, analysis and interpretation. My personal research interests are to understand the pathology of natural and experimental animal models of disease, particularly as they relate to the nervous system.

 

Heather Shive, DVM, PhD, ACVP

Molecular Pathologist, Comparative Pathology Core and Assistant Professor, Dept. of Population, Health, and Pathobiology

Cancers develop a broad spectrum of genetic disruptions, and it is often difficult to identify changes that contribute to tumor development. The zebrafish model (Danio rerio) is a powerful tool for analyzing genetic contributors to cancer risk: zebrafish exhibit conserved genetic susceptibility to cancer, are highly amenable to genetic manipulation, and can be analyzed in large numbers. The long-term goal of my research program is to investigate genetic mediators of carcinogenesis with the zebrafish model. This research will additionally incorporate environmental and toxicologic factors that may act in synergy with genetic factors to influence cancer risk.