Carolyn Mattingly

Bio

Hi! I’m Carolyn Mattingly and I got to science and NC State via a circuitous route. I earned a BA in Art History from Oberlin College. After exploring the country and mountains of the western US, I earned a PhD in Molecular Toxicology from Tulane University and conducted postdoctoral research in Pharmacology at the Weill College of Medicine at Cornell University. My research has focused on trying to understand the effects of environmental exposures on human development and health. To do this, I’ve been working with an amazing team of scientists and software developers to build and expand the Comparative Toxicogenomics Database (CTD) since 2001. This resource provides data on the complex connections between chemicals, genes and proteins, phenotypes, diseases, and exposure information with tools to help users ask questions about chemicals in the environment, how they work, and whether they might be contributing to common chronic diseases from cancer to neurodevelopment disorders.  I’m also the Director of NC State’s Superfund Research Program Center, The Center for Environmental and Health Effects of PFAS, which brings together scientists, community groups, students and diverse stakeholders to try to understand PFAS exposure, toxicity, and improve remediation.

Publications

• Comparative toxicogenomics database's 20th anniversary: update 2025 , NUCLEIC ACIDS RESEARCH (2024)
• Transforming environmental health datasets from the comparative toxicogenomics database into chord diagrams to visualize molecular mechanisms , FRONTIERS IN TOXICOLOGY (2024)
• CTD tetramers: a new online tool that computationally links curated chemicals, genes, phenotypes, and diseases to inform molecular mechanisms for environmental health , TOXICOLOGICAL SCIENCES (2023)
• Developmental cadmium exposure disrupts zebrafish vestibular calcium channels interfering with otolith formation and inner ear function , NEUROTOXICOLOGY (2023)
• Comparative Toxicogenomics Database (CTD): update 2023 , NUCLEIC ACIDS RESEARCH (2022)
• CTD anatomy: Analyzing chemical-induced phenotypes and exposures from an anatomical perspective, with implications for environmental health studies , CURRENT RESEARCH IN TOXICOLOGY (2021)
• Predicting molecular mechanisms, pathways, and health outcomes induced by Juul e-cigarette aerosol chemicals using the Comparative Toxicogenomics Database , CURRENT RESEARCH IN TOXICOLOGY (2021)
• Regulatory status of pesticide residues in cannabis: Implications to medical use in neurological diseases , CURRENT RESEARCH IN TOXICOLOGY (2021)
• Beyond the looking glass: recent advances in understanding the impact of environmental exposures on neuropsychiatric disease , NEUROPSYCHOPHARMACOLOGY (2020)
• Comparative Toxicogenomics Database (CTD): update 2021 , NUCLEIC ACIDS RESEARCH (2020)