James Bonner

Bio

The goal of the Bonner Lab is to explore and investigate mechanisms of environmental lung diseases (asthma, fibrosis, cancer) caused by emerging toxicants that pose a threat to human health and the environment. Our work is focused on investigating mechanisms of pulmonary toxicity caused by engineered nanomaterials (ENMs); tiny particles or fibers designed at the atomic scale that are increasingly used in a variety of consumer products. Of particular interest is determining the toxic potential of ENMs in susceptible populations and individuals with pre-existing diseases, especially asthma.

Publications

• House Dust Mite Proteins Adsorb on Multiwalled Carbon Nanotubes Forming an Allergen Corona That Intensifies Allergic Lung Disease in Mice , ACS NANO (2024)
• House dust mite extract forms a der p 2 corona on multi-walled carbon nanotubes: implications for allergic airway disease , ENVIRONMENTAL SCIENCE-NANO (2023)
• Role of the protease-activated receptor-2 (PAR2) in the exacerbation of house dust mite-induced murine allergic lung disease by multi-walled carbon nanotubes , PARTICLE AND FIBRE TOXICOLOGY (2023)
• Pulmonary exposure of mice to ammonium perfluoro(2-methyl-3-oxahexanoate) (GenX) suppresses the innate immune response to carbon black nanoparticles and stimulates lung cell proliferation , INHALATION TOXICOLOGY (2022)
• Synergistic induction of IL-6 production in human bronchial epithelial cells in vitro by nickel nanoparticles and lipopolysaccharide is mediated by eSTAT3 and C/EBP beta , TOXICOLOGY IN VITRO (2022)
• Femtosecond pulsed laser microscopy: a new tool to assess the in vitro delivered dose of carbon nanotubes in cell culture experiments , PARTICLE AND FIBRE TOXICOLOGY (2021)
• Osteopontin mRNA expression by rat mesothelial cells exposed to multi-walled carbon nanotubes as a potential biomarker of chronic neoplastic transformation in vitro , TOXICOLOGY IN VITRO (2021)
• STAT6-dependent exacerbation of house dust mite-induced allergic airway disease in mice by multi-walled carbon nanotubes , NANOIMPACT (2021)
• Sex Differences in Pulmonary Eicosanoids and Specialized Pro-Resolving Mediators in Response to Ozone Exposure , TOXICOLOGICAL SCIENCES (2021)
• Interaction of Nanomaterials with the Immune System , (2020)