Jonathan Hall
Asst Professor
Department of Biological Sciences
Toxicology Building 2202D
Bio
Research in the Hall Lab is focused on the identification and characterization of genes and signaling pathways that determine susceptibility to skin cancer. We are especially interested in how cells respond to environmental stress (such as solar UVB-induced DNA damage) when making the decision to live or to trigger regulated cell death.
Publications
- Mutant Nrf2E79Q enhances the promotion and progression of a subset of oncogenic Ras keratinocytes and skin tumors , REDOX BIOLOGY (2024)
- C/EBP beta deficiency enhances the keratinocyte innate immune response to direct activators of cytosolic pattern recognition receptors , INNATE IMMUNITY (2023)
- TIN2 is an architectural protein that facilitates TRF2-mediated trans- and cis-interactions on telomeric DNA , NUCLEIC ACIDS RESEARCH (2021)
- C/EBP beta suppresses keratinocyte autonomous type 1 IFN response and p53 to increase cell survival and susceptibility to UVB-induced skin cancer , CARCINOGENESIS (2019)
- C/EBPβ deletion in oncogenic Ras skin tumors is a synthetic lethal event , Cell Death & Disease (2018)
- Role of p53 in the chronic pulmonary immune response to tangled or rod-like multi-walled carbon nanotubes , NANOTOXICOLOGY (2018)
- Long noncoding RNA lincRNA-p21 is the major mediator of UVB-induced and p53-dependent apoptosis in keratinocytes , CELL DEATH & DISEASE (2015)
- C/EBPα regulates CRL4Cdt2-mediated degradation of p21 in response to UVB-induced DNA damage to control the G1/S checkpoint , Cell Cycle (2014)
- C/EBP alpha Expression Is Downregulated in Human Nonmelanoma Skin Cancers and Inactivation of C/EBP alpha Confers Susceptibility to UVB-Induced Skin Squamous Cell Carcinomas , JOURNAL OF INVESTIGATIVE DERMATOLOGY (2011)