Michael Cowley

Bio

The goals of the Cowley Lab are to understand how the developmental environment impacts the epigenetic regulation of the genome, and to understand the functional consequences of this for development and disease.

Publications

• Grb7, Grb10 and Grb14, encoding the growth factor receptor-bound 7 family of signalling adaptor proteins have overlapping functions in the regulation of fetal growth and post-natal glucose metabolism , BMC BIOLOGY (2024)
• LncRNA Tuna is activated in cadmium-induced placental insufficiency and drives the NRF2-mediated oxidative stress response , FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2023)
• Epigenetic control of the imprinted growth regulator Cdkn1c in cadmium-induced placental dysfunction , EPIGENETICS (2022)
• Genomic map of candidate human imprint control regions: the imprintome , EPIGENETICS (2022)
• The imprinted gene Zac1 regulates steatosis in developmental cadmium-induced nonalcoholic fatty liver disease , TOXICOLOGICAL SCIENCES (2022)
• Zac1 and the Imprinted Gene Network program juvenile NAFLD in response to maternal metabolic syndrome , HEPATOLOGY (2022)
• Imprinted Gene Expression and Function of the Dopa Decarboxylase Gene in the Developing Heart , FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)
• Transcriptomic, proteomic, and metabolomic analyses identify candidate pathways linking maternal cadmium exposure to altered neurodevelopment and behavior , SCIENTIFIC REPORTS (2021)
• Transcription of intragenic CpG islands influences spatiotemporal host gene pre-mRNA processing , NUCLEIC ACIDS RESEARCH (2020)
• Maternal cadmium exposure in the mouse leads to increased heart weight at birth and programs susceptibility to hypertension in adulthood , SCIENTIFIC REPORTS (2019)