Yoshiaki Tsuji

Bio

Dr. Tsuji’s research is centered on gene regulation and signaling pathways involved in iron homeostasis and antioxidant defense mechanisms under the exposure of chemotherapeutic agents such as cisplatin and environmental toxicants including arsenic and cadmium. In particular, Dr. Tsuji’s research is focused on the molecular mechanism through which cellular iron transport and storage are coordinately regulated to protect cells from oxidative stress induced by the chemical exposure, and how perturbation of iron metabolism by chemical exposure causes or exacerbates human disease such as cancer and neurodegeneration.

Publications

• LncRNA Tuna is activated in cadmium-induced placental insufficiency and drives the NRF2-mediated oxidative stress response , FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2023)
• Optimization of Biotinylated RNA or DNA Pull-Down Assays for Detection of Binding Proteins: Examples of IRP1, IRP2, HuR, AUF1, and Nrf2 , INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)
• Transmembrane protein western blotting: Impact of sample preparation on detection of SLC11A2 (DMT1) and SLC40A1 (ferroportin) , PLOS ONE (2020)
• Iron-induced transferrin receptor-1 mRNA destabilization: A response to "Neither miR-7-5p nor miR-141-3p is a major mediator of iron-responsive transferrin receptor-1 mRNA degradation" , RNA (2019)
• Perturbation of Iron Metabolism by Cisplatin through Inhibition of Iron Regulatory Protein 2 , CELL CHEMICAL BIOLOGY (2018)
• Nuclear lamins and progerin are dispensable for antioxidant Nrf2 response to arsenic and cadmium , CELLULAR SIGNALLING (2017)
• Arsenic-Induced Activation of the Homeodomain-Interacting Protein Kinase 2 (HIPK2) to cAMP-Response Element Binding Protein (CREB) Axis , JOURNAL OF MOLECULAR BIOLOGY (2016)
• Siderophores in Iron Metabolism: From Mechanism to Therapy Potential , TRENDS IN MOLECULAR MEDICINE (2016)
• TAK1 Regulates the Nrf2 Antioxidant System Through Modulating p62/SQSTM1 , ANTIOXIDANTS & REDOX SIGNALING (2016)
• Coordinated regulation of Nrf2 and histone H3 serine 10 phosphorylation in arsenite-activated transcription of the human heme oxygenase-1 gene , BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS (2015)