“Telomeres are Partly Shielded from Ultraviolet-Induced Damage and Proficient for Nucleotide Excision Repair of Photoproducts”

North Carolina State University Researcher and CHHE Member, Hong Wang, and her colleagues at NC State and the University of Pittsburgh have found that telomeres are protected from ultraviolet (UV) light-induced DNA damage and that specific UV-induced photolesions in DNA are repaired more efficiently in the telomere than in the overall genome.  This work was partially supported by a CHHE Pilot Project awarded to Hong Wong.  Nonmelanoma skin cancer (NMSC) is the most common cancer in the United States. The […]

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“Lead Exposure during Early Human Development and DNA Methylation of Imprinted Gene Regulatory Elements in Adulthood”

A team of researchers led by North Carolina State University CHHE biologists Cathrine Hoyo and Randy Jirtle have found links between lead exposure in children and epigenetic alterations in regulatory regions of genes that are imprinted and known to be critical in growth regulation and brain development. These alterations seem to persist into adulthood, with more profound effects in males. Their study sheds more light on the long-term effects of early lead exposure on DNA and may help to develop […]

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CHHE Funds 6 Pilot Projects

CHHE received 26 pilot project applications from investigators at NC State, North Carolina Central University and East Carolina University.  Six highly ranked pilot projects were selected for funding.  The successful pilot project applicants were from Dept. of Biological Sciences, College of Sciences; Dept. of Crop Science, College of Agriculture and Life Sciences;  Dept. of Biomedical Sciences, College of Veterinary Medicine; Dept. of Civil, Construction, and Environmental Engineering, College of Engineering and Dept. of Pharmacology and Toxicology, East Carolina University.  We […]

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CHHE Receives $6.5 Million from NIEHS to Study Effect of Environment on Human Health

News Release 4/20/15 – Researchers from North Carolina State University’s Center for Human Health and the Environment (CHHE) have received a five-year, $6.5 million grant from the National Institute of Environmental Health Sciences (NIEHS) to investigate the effects of environmental factors on human health. The primary mission of the CHHE is to understand how human health, of both individuals and populations, is affected by environmental factors and to use this knowledge to prevent or reduce negative environmental impacts on health. Through interdisciplinary researchand collaboration, […]

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2015 Pilot Project Announcement – Request for Applications

The Center for Human Heath and the Environment (CHHE) is announcing its request for applications (RFA) for pilot project proposals for 2015.  Applications will be due on June 15th, 2015. The CHHE anticipates proposals from across the NCSU campus, ECU Brody School of Medicine, and NC Central University. The CHHE aims to enhance and integrate basic and translational research from molecules to cells to animal models to human populations using cutting-edge technologies and computational approaches to understand the impacts of […]

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