Agricultural Pesticide Exposure and Chronic Kidney Disease: New Findings and More Questions

Researchers at NC State, NIEHS, and UNC Chapel Hill recently published the first article to link agricultural pesticide use to end stage renal disease. UNC doctoral student Jill Lebov worked with Dr. Jane Hoppin at NC State and researchers at NIEHS and UNC Chapel Hill to assess personal use of 39 different pesticides by over 55,000 farmers in the Agricultural Health Study (, a prospective study of farmers in North Carolina and Iowa. End stage renal disease is the last […]

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Jane A. Hoppin - Jill F. Lebov

Carolyn Mattingly Named University Faculty Scholar

Carolyn Mattingly is an Associate Professor in the Department of Biological Sciences and Co-Director of the CHHE’s Integrative Health Sciences Facility Core.  Her lab uses bioinformatics and comparative genomics approaches to understand the complex interactions between our environment and human health. She also leads the Comparative Toxicogenomics Database, which links research about chemicals genes and diseases to better predict how chemicals will affect our health. Carolyn wears many scholar hats, she is: an educator, teaching undergraduates in the classroom and […]

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“Telomeres are Partly Shielded from Ultraviolet-Induced Damage and Proficient for Nucleotide Excision Repair of Photoproducts”

North Carolina State University Researcher and CHHE Member, Hong Wang, and her colleagues at NC State and the University of Pittsburgh have found that telomeres are protected from ultraviolet (UV) light-induced DNA damage and that specific UV-induced photolesions in DNA are repaired more efficiently in the telomere than in the overall genome.  This work was partially supported by a CHHE Pilot Project awarded to Hong Wong.  Nonmelanoma skin cancer (NMSC) is the most common cancer in the United States. The […]

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“Lead Exposure during Early Human Development and DNA Methylation of Imprinted Gene Regulatory Elements in Adulthood”

A team of researchers led by North Carolina State University CHHE biologists Cathrine Hoyo and Randy Jirtle have found links between lead exposure in children and epigenetic alterations in regulatory regions of genes that are imprinted and known to be critical in growth regulation and brain development. These alterations seem to persist into adulthood, with more profound effects in males. Their study sheds more light on the long-term effects of early lead exposure on DNA and may help to develop […]

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CHHE Funds 6 Pilot Projects

CHHE received 26 pilot project applications from investigators at NC State, North Carolina Central University and East Carolina University.  Six highly ranked pilot projects were selected for funding.  The successful pilot project applicants were from Dept. of Biological Sciences, College of Sciences; Dept. of Crop Science, College of Agriculture and Life Sciences;  Dept. of Biomedical Sciences, College of Veterinary Medicine; Dept. of Civil, Construction, and Environmental Engineering, College of Engineering and Dept. of Pharmacology and Toxicology, East Carolina University.  We […]

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