Metabolomics and Small Molecules
Metabolomics is the study of low molecular weight substrates, intermediates, and products of metabolism which are often assessed in complex samples such as cells, tissues, or biological fluids. Metabolomics makes it possible to uniquely evaluate (metabotype) the biochemistry of an individual or system and is used to determine the molecular changes arising from disease, dysfunction, disorder, and therapeutic or adverse effects of xenobiotics.
In general, the Metabolomics Section will utilize both targeted and discovery metabolomic and exposomic measurements to evaluate different systems. For these analyses, the small molecules are extracted from biological or environmental samples and then analyzed using either targeted or discovery schemes.
Applications in Targeted Metabolomics and Exposomics
- Absolute quantification of target small molecules using their heavy-labeled versions
- Relative quantification of statistically significant small molecules without their heavy-labeled versions
- Verification of pathway knockout experiments
Applications in Discovery Metabolomics and Exposomics
- Detection of novel small molecule features changing in biological and environmental samples
- Identification of new small molecules not known to exist in certain sample types
Multiple suites of software are available for data analyses. Data can also be transferred to Bioinformatics Research Center- and CHHE-supported servers and analyzed by the CHHE Environmental Data Science Group.
All requests for consultation, support and services must go through the STC portal. You can also watch a short video from Dr. Baker for more information.